Associate Principal at Guidehouse Digital LLC · Contracted Senior Medical Imaging Deep Learning Image Scientist at NIH / National Library of Medicine (NLM) · Ph.D. Information & Communication Engineering, Anna University · 15+ years academic · 9+ years research expertise.
"I build AI tools that can genuinely support clinical decision-making, especially where resources are limited, and I care deeply about making those systems reliable, fair, and useful in the real world."
Dr. Sivarama Krishnan Rajaraman is an Associate Principal at Guidehouse Digital LLC and works with the Division of Intramural Research at the National Library of Medicine, part of the U.S. National Institutes of Health, as a Senior Medical Imaging Deep Learning Image Scientist. He earned his Ph.D. in Information and Communication Engineering from Anna University in India and later completed postdoctoral research at NLM and NIH.
His work sits at the intersection of artificial intelligence and clinical medicine. Over the years, he has focused on problems such as computer-aided TB and COVID-19 screening, mobile malaria diagnostics, generative modeling for data scarcity, and rigorous evaluation for real-world deployment, including calibration, uncertainty, fairness, and domain shift.
His research is closely aligned with the broader push for trustworthy and responsible clinical AI in public health. In practice, that means building systems that are not only accurate, but also transparent, equitable, and dependable when they are used in high-impact settings.
Computer-aided detection and severity quantification from chest radiographs, including pediatric cohorts, dual-projection modeling, lesion segmentation, and uncertainty-aware triage pipelines deployed at scale.
Mobile and AI-enabled detection of malaria parasites via smartphone-based microscopy, designed for low-resource, field-deployable point-of-care settings with model interpretability.
Tackling limited labeled medical data using GANs, latent diffusion models, and multimodal learning with LLM-generated and expert-curated text for robust clinical translation.
Systems research in model calibration, uncertainty quantification, inter-reader variability, algorithmic fairness, and cross-domain robustness building defensible clinical AI.
Annual citation counts sourced from Google Scholar profile (bHPu9eIAAAAJ). Update the annualData array in the script each year to keep the chart current.
Smartphone-based AI malaria diagnostic tool converting commodity Android devices into field-deployable microscopy units for blood-smear screening at the point of care.
Learn More ↗Deep learning framework for pediatric chest X-ray analysis with domain adaptation, class-imbalance handling via latent diffusion, and failure-mode characterization.
Learn More ↗AI models for radiographic severity scoring using self-supervised contrastive learning and large-vision-model knowledge adaptation for scalable triage beyond binary detection.
Learn More ↗Calibration and fairness pipelines for medical imaging AI including uncertainty quantification, inter-annotator agreement analysis, and cross-domain robustness evaluation.
Learn More ↗Real-time AI system for cardiac parameter estimation from echocardiography images, including open-world view classification U.S. Patent filed 2022.
Learn More ↗Combining real and synthetic image-text data to overcome limited training datasets in multimodal medical AI using LLM-generated and expert-curated radiology text.
Learn More ↗Associate Editor / Editorial Board Member, PLOS ONE
Editorial Board Member, PLOS Digital Health
Editorial Board Member, PeerJ Computer Science
Organizer of special issues and workshops at international AI and medical imaging conferences
Top 1% reviewer recognition on Publons (2017–18, 2018–19)
Active peer reviewer for 100+ journals and conferences including The Lancet Digital Health, Nature Scientific Reports, IEEE Transactions on Medical Imaging, PLOS ONE, Medical Image Analysis, and more.
Best Employee Award (2018, 2020); Special Act or Service Group Award, NLM/NIH (2018)
IEEE Best Project Award (AT&T Bell Laboratories, 2000)
I welcome partnerships in medical AI, dataset sharing initiatives, joint publications, and co-organization of workshops and special journal issues. If you are working at the intersection of AI and clinical medicine, let's connect.